anti-Haptoglobin antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes Haptoglobin
  • 反应物种: Hu
  • 应用: FACS, ICC/IF, WB
  • 特异性: The antibody was raised by the immunogen coresponding to a.a. 296-322 of human haptoglobin which expect recognizes to full length and Haptoglobin beta chain (40 kDa, 245 amino acids unglycosylated 35 kDa).
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: Haptoglobin
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG55106
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes Haptoglobin
反应物种Hu
应用FACS, ICC/IF, WB
特异性The antibody was raised by the immunogen coresponding to a.a. 296-322 of human haptoglobin which expect recognizes to full length and Haptoglobin beta chain (40 kDa, 245 amino acids unglycosylated 35 kDa).
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称Haptoglobin
抗原物种Human
抗原KLH-conjugated synthetic peptide corresponding to aa. 296-322 of Human Haptoglobin.
偶联标记Un-conjugated
別名HPA1S; Haptoglobin; BP; HP2ALPHA2; Zonulin
应用说明
应用建议
应用推荐稀释比
FACS1:10 - 1:50
ICC/IF1:10 - 1:50
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein A and immunogen peptide
缓冲液PBS and 0.09% (W/V) Sodium azide
抗菌剂0.09% (W/V) Sodium azide
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 3240 Human HP

Swiss-port # P00738 Human Haptoglobin

基因名称HP
全名haptoglobin
背景介绍This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
生物功能As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. [UniProt]
研究领域Cell Biology and Cellular Response antibody
预测分子量45 kDa
检测图片 (4)
  • ARG55106 anti-Haptoglobin antibody WB image

    Western blot: 30 µg of HepG2 cell lysate stained with ARG55106 anti-Haptoglobin antibody at 1:1000 dilution.

  • ARG55106 anti-Haptoglobin antibody ICC/IF image

    Immunofluorescence: MDA-MB-435 cells stained with ARG55106 anti-Haptoglobin antibody (green). DAPI (blue) for nuclear staining.

  • ARG55106 anti-Haptoglobin antibody IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human hepatocarcinoma stained with ARG55106 anti-Haptoglobin antibody.

  • ARG55106 anti-Haptoglobin antibody FACS image

    Flow Cytometry: MDA-MB435 cells stained with ARG55106 anti-Haptoglobin antibody (right histogram) or without primary antibody control (left histogram), followed by incubation with FITC labelled secondary antibody.

参考文献

Effect of haptoglobin on the treatment of chronic hepatitis B with interferon.

WB / Human

Lv Lin-Ling et al.
Experimental and Therapeutic Medicine.,  (2019)

publication_link

 

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