anti-HBsAg antibody [SQab30330]

CAT.NO. : ARG67036

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Size:

100 μl

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Product Details

概述

产品描述	Recombinantrabbit Monoclonal antibody [SQab30330] recognizes HBSAg
反应物种	HBV
应用	IHC-P
宿主	Rabbit
克隆	Monoclonal
克隆号	SQab30330
同位型	IgG
靶点名称	HBSAg
抗原物种	Human
抗原	Recombinant protein of Human HBSAg.
偶联标记	Un-conjugated
Protein Full name	Large envelope protein

应用说明

应用建议

应用	推荐稀释比
IHC-P	1:50 - 1:100

应用说明

The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

阳性对照

HBV infected liver

属性

形式	Liquid
纯化	Purification with Protein A.
缓冲液	PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA.
抗菌剂	0.01% Sodium azide
稳定剂	40% Glycerol and 0.05%BSA
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

基因名称	S
全名	Large envelope protein
背景介绍	Systematic vaccination of individuals at risk of exposure to the virus has been the main method of controlling the morbidity and mortality associated with hepatitis B. The first hepatitis B vaccine was manufactured by the purification and inactivation of HBsAg obtained from the plasma of chronic hepatitis B virus carriers. The vaccine is now produced by recombinant DNA techniques and expression of the S isoform in yeast cells. The pre-S region do not seem to induce strong enough antigenic response.
生物功能	The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein. [UniProt]
细胞定位	Cytoplasm
预测分子量	42 kDa
翻译后修饰	Isoform M is N-terminally acetylated by host at a ratio of 90%, and N-glycosylated by host at the pre-S2 region.

检测图片 (1)

ARG67036 anti-HBSAg antibody [SQab30330] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded HBV infected liver stained with ARG67036 anti-HBSAg antibody [SQab30330].

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