anti-Heme Oxygenase 1 antibody [1F12.A6]
![anti-Heme Oxygenase 1 antibody [1F12.A6]](/upload/image/products/ARG54649_210_205.jpg)
![anti-Heme Oxygenase 1 antibody [1F12.A6]](/upload/image/products/ARG54649.jpg)
Key features and details
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CAT.NO. : ARG54649
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [1F12.A6] recognizes Heme Oxygenase 1 |
|---|---|
| 反应物种 | Hu, Ms, Bov |
| 应用 | ELISA, WB |
| 特异性 | This antibody recognizes human, mouse, and bovine HO-1. Other species have not been tested. It does not cross-react with HO-2. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 1F12.A6 |
| 同位型 | IgG1 |
| 靶点名称 | Heme Oxygenase 1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around aa. 1-30 of Human heme-oxygenase 1. |
| 偶联标记 | Un-conjugated |
| 別名 | bK286B10; Heme oxygenase 1; HO-1; EC 1.14.99.3; HMOX1D; HSP32 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human cell line lysates such as A431, A549, HeLa, HepG2, Jurkat, and MCF7. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4) |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | HMOX1 |
| 全名 | heme oxygenase 1 |
| 背景介绍 | Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008] |
| 生物功能 | Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. [UniProt] |
| 产品亮点 | Related products: Heme Oxygenase 1 antibodies; Heme Oxygenase 1 ELISA Kits; Heme Oxygenase 1 Duos / Panels; Anti-Mouse IgG secondary antibodies; Related news: Keap1-Nrf2-ARE antibody panel is launched |
| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 33 kDa |
检测图片 (1)
ARG54649 anti-Heme Oxygenase 1 antibody [1F12.A6] WB image
Western blot: GBC-SD and SGC-996 cell stained with ARG54649 anti-Heme Oxygenase 1 antibody [1F12.A6], ARG41439 anti-Ferritin Heavy Chain antibody and ARG62346 anti-beta Actin antibody [BA3R]
.From Desen Fan et al. Heliyon. (2024), doi: 10.1016/j.heliyon.2024.e30260, Fig. 4B.
参考文献
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WB / Human
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