anti-HIPK3 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes HIPK3
  • 反应物种: Hu
  • 预测物种: Ms, Rat
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: HIPK3
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG54855
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes HIPK3
反应物种Hu
预测物种Ms, Rat
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称HIPK3
抗原物种Human
抗原KLH-conjugated synthetic peptide corresponding to aa. 1127-1156 (C-terminus) of Human HIPK3.
偶联标记Un-conjugated
別名FIST3; Fas-interacting serine/threonine-protein kinase; Androgen receptor-interacting nuclear protein kinase; YAK1; PKY; Homeodomain-interacting protein kinase 3; FIST; DYRK6; EC 2.7.11.1; Homolog of protein kinase YAK1; ANPK
应用说明
应用建议
应用推荐稀释比
IHC-PAssay-dependent
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein G.
缓冲液PBS and 0.09% (W/V) Sodium azide
抗菌剂0.09% (W/V) Sodium azide
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 10114 Human HIPK3

Swiss-port # Q9H422 Human Homeodomain-interacting protein kinase 3

基因名称HIPK3
全名homeodomain interacting protein kinase 3
生物功能Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). [UniProt]
细胞定位Cytoplasm. Nucleus
研究领域Cell Biology and Cellular Response antibody; Cell Death antibody; Gene Regulation antibody; Signaling Transduction antibody
预测分子量134 kDa
翻译后修饰Autophosphorylated, but autophosphorylation is not required for catalytic activity.
May be sumoylated.
检测图片 (1)
  • ARG54855 anti-HIPK3 antibody IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human cancer tissue stained with ARG54855 anti-HIPK3 antibody.

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