anti-Histone H2A.X acetyl (Lys9) antibody [RM446]
![anti-Histone H2A.X acetyl (Lys9) antibody [RM446]](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
Key features and details
- 产品描述:
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- 宿主:
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- 靶点名称:
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Brand:
CAT.NO. : ARG45026
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Product Details
概述
| 产品描述 | Rabbit monoclonal antibody recognizes Histone H2A.X acetyl (Lys9). |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 特异性 | This antibody reacts to Histone H2A.X acetylated at Lysine 9 (K9ac). No cross reactivity with non-modified Lysine 9 or other acetylated Lysines in histone H2A. |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | RM446 |
| 同位型 | IgG |
| 靶点名称 | Histone H2A.X |
| 抗原物种 | Human |
| 抗原 | A peptide corresponding to acetyl-Histone H2A.X (Lys9). |
| 偶联标记 | Un-conjugated |
| 別名 | H2AX; H2A.X Variant Histone; H2AFX; H2A Histone Family Member X; Histone H2A.X; Histone H2AX; H2A Histone Family, Member X; H2AX Histone; H2A.X; H2A/X; H2a/X |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 稳定剂 | 50% Glycerol, 1% BSA and 0.09% |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | H2AX |
| 全名 | H2A.X Variant Histone |
| 背景介绍 | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015] |
| 生物功能 | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. [Uniprot] |
| 细胞定位 | Chromosome, Nucleosome core, Nucleus. [Uniprot] |
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