anti-HLA G antibody [SQab30313]

Key features and details

  • 产品描述: Recombinantrabbit Monoclonal antibody [SQab30313] recognizes HLA G
  • 反应物种: Hu
  • 应用: IHC-P
  • 宿主: Rabbit
  • 克隆: Monoclonal
  • 克隆号: SQab30313
  • 同位型: IgG
  • 靶点名称: HLA G
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG67037
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Product Details
概述
产品描述Recombinantrabbit Monoclonal antibody [SQab30313] recognizes HLA G
反应物种Hu
应用IHC-P
宿主Rabbit
克隆Monoclonal
克隆号SQab30313
同位型IgG
靶点名称HLA G
抗原物种Human
抗原Recombinant protein of Human HLA G.
偶联标记Un-conjugated
Protein Full nameHLA class I histocompatibility antigen, alpha chain G
別名HLA-G, Major Histocompatibility Complex, Class I, G, HLA Class I Histocompatibility Antigen, Alpha Chain G, HLA-G Histocompatibility Antigen, Class I, G, MHC Class I Antigen G, B2 Microglobulin, HLA G Antigen, Mutant MHC Class Ib Antigen, Mutant MHC Class I Antigen, MHC Class Ib Antigen, HLA-6.0, MHC-G, HLAG
应用说明
应用建议
应用推荐稀释比
IHC-P1:50 - 1:100
应用说明The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Human placenta
属性
形式Liquid
纯化Purification with Protein A.
缓冲液PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA.
抗菌剂0.01% Sodium azide
稳定剂40% Glycerol and 0.05%BSA
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 3135 Human HLA-G

Swiss-port # P17693 Human HLA class I histocompatibility antigen, alpha chain G

基因名称HLA-G
全名Major Histocompatibility Complex, Class I, G
背景介绍HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
生物功能Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface. In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins.Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance.Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. [Uniprot]
细胞定位Cell membrane, Cell projection, Endoplasmic reticulum, Endosome, Membrane
预测分子量38 kDa
翻译后修饰N-glycosylated.1 Publication. Soluble HLA class I histocompatibility antigen, alpha chain GProduced by proteolytic cleavage at the cell surface (shedding) by matrix metalloproteinase MMP2. [Uniprot]
检测图片 (1)
  • ARG67037 anti-HLA G antibody [SQab30313] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded human placenta stained with ARG67037 anti-HLA G antibody [SQab30313].

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