anti-hnRNP DL antibody
Key features and details
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- 反应物种:
- 应用:
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- 克隆:
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- 靶点名称:
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- 抗原:
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Brand:
CAT.NO. : ARG42845
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes hnRNP DL |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | hnRNP DL |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 261-420 of Human hnRNP DL (NP_112740.1). |
| 偶联标记 | Un-conjugated |
| 別名 | JKT41-binding protein; AU-rich element RNA-binding factor; HNRPDL; laAUF1; Protein laAUF1; HNRNP; Heterogeneous nuclear ribonucleoprotein D-like; hnRNP DL; LGMD1G; JKTBP; hnRNP D-like; JKTBP2 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | SW620 | ||||||
| 实际分子量 | ~ 40 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # O14979 Human Heterogeneous nuclear ribonucleoprotein D-like Swiss-port # Q3SWU3 Rat Heterogeneous nuclear ribonucleoprotein D-like |
|---|---|
| 基因名称 | HNRNPDL |
| 全名 | heterogeneous nuclear ribonucleoprotein D-like |
| 背景介绍 | This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011] |
| 生物功能 | Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. [UniProt] |
| 细胞定位 | Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent manner. [UniProt] |
| 预测分子量 | 46 kDa |
| 翻译后修饰 | Dimethylation of Arg-408 is probably of the asymmetric type. [UniProt] |
检测图片 (2)
ARG42845 anti-hnRNP DL antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG42845 anti-hnRNP DL antibody at 1:100 dilution.
ARG42845 anti-hnRNP DL antibody WB image
Western blot: 25 µg of SW620 cell lysate stained with ARG42845 anti-hnRNP DL antibody at 1:1000 dilution.
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