anti-IL10R subunit beta antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
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- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG43397
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes IL10R subunit beta |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | IL10R subunit beta |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 20-220 of Human IL10R subunit beta (NP_000619.3). |
| 偶联标记 | Un-conjugated |
| 別名 | Cytokine receptor family 2 member 4; CRFB4; IL-10RB; CRF2-4; Interleukin-10 receptor subunit 2; IL-10R2; D21S66; CD antigen CDw210b; IL-10R subunit 2; Interleukin-10 receptor subunit beta; D21S58; Cytokine receptor class-II member 4; CDW210B; IL-10R subunit beta; IL-10 receptor subunit beta |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Jurkat and U-87MG | ||||||
| 实际分子量 | 37 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q08334 Human Interleukin-10 receptor subunit beta |
|---|---|
| 基因名称 | IL10RB |
| 全名 | interleukin 10 receptor, beta |
| 背景介绍 | The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008] |
| 生物功能 | Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 37 kDa |
检测图片 (3)
ARG43397 anti-IL10R subunit beta antibody ICC/IF image
Immunofluorescence: L929 cells stained with ARG43397 anti-IL10R subunit beta antibody at 1:100 dilution.
ARG43397 anti-IL10R subunit beta antibody WB image
Western blot: 25 µg of Jurkat cell lysate stained with ARG43397 anti-IL10R subunit beta antibody at 1:1000 dilution.
ARG43397 anti-IL10R subunit beta antibody WB image
Western blot: 25 µg of U-87MG cell lysate stained with ARG43397 anti-IL10R subunit beta antibody at 1:1000 dilution.
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