anti-IL17 / IL17A antibody [TC11-18H10] (low endotoxin)
![anti-IL17 / IL17A antibody [TC11-18H10] (low endotoxin)](/upload/image/20241105/8415bc38bc270b898ee2a90369a6c7fb.jpg)
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CAT.NO. : ARG21490
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Product Details
概述
| 产品描述 | Azide free and low endotoxin Rat Monoclonal antibody [TC11-18H10 ] recognizes IL17 / IL17A |
|---|---|
| 反应物种 | Ms |
| 应用 | ELISA, ELISPOT, FACS, Neut |
| 特异性 | Mouse IL-17A. |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | TC11-18H10 |
| 同位型 | IgG1, kappa |
| 靶点名称 | IL17 / IL17A |
| 抗原物种 | Mouse |
| 抗原 | E. coli-expressed mouse IL-17 |
| 偶联标记 | Un-conjugated |
| 別名 | IL-17A; Interleukin-17A; IL-17; CTLA8; IL17; CTLA-8; Cytotoxic T-lymphocyte-associated antigen 8 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | Neutralizing: The clone has been used to neutralize/block IL17 activity and it led to suppress IL1 alpha, IL1 beta, IL6 and IFN gamma releasing in CHS mouse model.* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化说明 | Low endotoxin |
| 缓冲液 | PBS |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IL17A |
| 全名 | interleukin 17A |
| 背景介绍 | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] |
| 生物功能 | Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [UniProt] |
| 产品亮点 | Related products: IL17 antibodies; IL17 ELISA Kits; IL17 recombinant proteins; Anti-Rat IgG secondary antibodies; Related news: HMGB1, a biomarker and therapeutic target in COVID-19 |
| 预测分子量 | 18 kDa |
| 翻译后修饰 | Found both in glycosylated and nonglycosylated forms. |
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