anti-IL6R alpha antibody [B-R6] (FITC)
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CAT.NO. : ARG23319
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Product Details
概述
| 产品描述 | FITC-conjugated Mouse Monoclonal antibody [B-R6] recognizes IL6R alpha |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 特异性 | This antibody recognizes the Interleukin-6 Ra subunit, IL-6 Ra, IL-6 R, a 80 kDa protein. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | B-R6 |
| 同位型 | IgG1 |
| 靶点名称 | IL6R alpha |
| 抗原物种 | Human |
| 抗原 | IL6R alpha transfected CHO cell line |
| 偶联标记 | FITC |
| 別名 | IL-6R-alpha; CD126; IL6RA; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL6Q; CD antigen CD126; IL-6R 1; IL-6RA; gp80; IL6RQ; Interleukin-6 receptor subunit alpha; IL-6R-1; Membrane glycoprotein 80 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | FACS: Use 10 µl to label 10^6 cells or 100 µl of whole blood. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | PBS, 0.09% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 5% BSA |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P08887 Human Interleukin-6 receptor subunit alpha |
|---|---|
| 基因名称 | IL6R |
| 全名 | interleukin 6 receptor |
| 背景介绍 | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011] |
| 生物功能 | Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. [UniProt] |
| 预测分子量 | 52 kDa |
| 翻译后修饰 | A short soluble form may also be released from the membrane by proteolysis. [UniProt] |
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