anti-KChIP2 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes KChIP2
  • 反应物种: Hu, Ms, Rat
  • 预测物种: Chk
  • 应用: FACS, ICC/IF, IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: KChIP2
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG59333
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes KChIP2
反应物种Hu, Ms, Rat
预测物种Chk
应用FACS, ICC/IF, IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称KChIP2
抗原物种Human
抗原Synthetic peptide corresponding to aa. 78-112 of Human KChIP2. (DEFELSTVCHRPEGLEQLQEQTKFTRKELQVLYR)
偶联标记Un-conjugated
別名Potassium channel-interacting protein 2; A-type potassium channel modulatory protein 2; Kv channel-interacting protein 2; Cardiac voltage-gated potassium channel modulatory subunit; KCHIP2; KChIP2
应用说明
应用建议
应用推荐稀释比
FACS1:150 - 1:500
ICC/IF1:200 - 1:1000
IHC-P0.5 - 1 µg/ml
WB0.1 - 0.5 µg/ml
应用说明IHC-P: Antigen Retrieval: By heat mediation.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA.
抗菌剂0.05% Sodium azide
稳定剂5% BSA
浓度0.5 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 30819 Human KCNIP2

GeneID: 56817 Rat KCNIP2

GeneID: 80906 Mouse KCNIP2

基因名称KCNIP2
全名Kv channel interacting protein 2
背景介绍This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]
生物功能Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity). [UniProt]
细胞定位Isoform 1: Cell membrane; Lipid-anchor. Note=Detected on lipid rafts (By similarity). Isoform 2: Cell membrane; Lipid-anchor. Isoform 6: Cell membrane; Lipid-anchor. [UniProt]
预测分子量31 kDa
翻译后修饰Palmitoylated. Palmitoylation enhances association with the plasma membrane. [UniProt]
检测图片 (6)
  • ARG59333 anti-KChIP2 antibody ICC/IF image

    Immunofluorescence: SH-SY5Y cells were blocked with 10% goat serum and then stained with ARG59333 anti-KChIP2 antibody (green) at 2 µg/ml dilution, overnight at 4°C. DAPI (blue) for nuclear staining.

  • ARG59333 anti-KChIP2 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Mouse brain stained with ARG59333 anti-KChIP2 antibody.

  • ARG59333 anti-KChIP2 antibody WB image

    Western blot: 50 ug of Rat brain, 50 ug of Rat cardiac muscle, 50 ug of Mouse cardiac muscle and 40 ug of 22RV1 whole cell lysates stained wtih ARG59333 anti-KChIP2 antibody at 0.5 ug/ml dilution.

  • ARG59333 anti-KChIP2 antibody FACS image

    Flow Cytometry: K562 cells were blocked with 10% normal goat serum and then stained with ARG59333 anti-KChIP2 antibody (blue) at 1 µg/10^6 cells for 30 min at 20°C, followed by incubation with DyLight®488 labelled secondary antibody. Isotype control antibody (green) was rabbit IgG (1 µg/10^6 cells) used under the same conditions. Unlabelled sample (red) was also used as a control.

  • ARG59333 anti-KChIP2 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human glioma stained with ARG59333 anti-KChIP2 antibody.

  • ARG59333 anti-KChIP2 antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat brain stained with ARG59333 anti-KChIP2 antibody.

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