anti-KCNA5 / Kv1.5 antibody
Key features and details
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- 预测物种:
- 应用:
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- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG40377
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes KCNA5 / Kv1.5 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Bov |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | KCNA5 / Kv1.5 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 583-613 of Human KCNA5. (LEKCNVKAKSNVDLRRSLYALCLDTSRETDL) |
| 偶联标记 | Un-conjugated |
| 別名 | KV1.5; HK2; HPCN1; Potassium voltage-gated channel subfamily A member 5; PCN1; ATFB7; Voltage-gated potassium channel HK2; HCK1; Voltage-gated potassium channel subunit Kv1.5 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | 67 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P22460 Human Potassium voltage-gated channel subfamily A member 5 |
|---|---|
| 基因名称 | KCNA5 |
| 全名 | potassium channel, voltage gated shaker related subfamily A, member 5 |
| 背景介绍 | Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012] |
| 生物功能 | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. Homotetrameric channels display rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation. [UniProt] |
| 细胞定位 | Cell membrane; Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 67 kDa |
| 翻译后修饰 | Sumoylated on Lys-221, and Lys-536, preferentially with SUMO3. Sumoylation regulates the voltage sensitivity of the channel. [UniProt] |
检测图片 (1)
ARG40377 anti-KCNA5 / Kv1.5 antibody WB image
Western blot: 40 µg of 293T, A549 and PANC whole cell lysates stained with ARG40377 anti-KCNA5 / Kv1.5 antibody at 0.5 µg/ml dilution.
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