anti-KCNJ8 / kir6.1 antibody [S366-60]

CAT.NO. : ARG23904

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Size:

50 μg

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Mouse Monoclonal antibody [S366-60] recognizes KCNJ8 / kir6.1
反应物种	Hu, Rat
预测物种	Ms
应用	ICC/IF, WB
宿主	Mouse
克隆	Monoclonal
克隆号	S366-60
同位型	IgG2a
靶点名称	KCNJ8 / kir6.1
抗原物种	Rat
抗原	Fusion protein corresponding to aa. 306-424 (Cytoplasmic C-terminus) of Rat KCNJ8 / kir6.1.
偶联标记	Un-conjugated
別名	ATP-sensitive inward rectifier potassium channel 8; Potassium channel, inwardly rectifying subfamily J member 8; uKATP-1; KIR6.1; Inward rectifier K

应用说明

应用建议

应用	推荐稀释比
ICC/IF	1:100
WB	1:1000

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

实际分子量

~ 40 kDa

属性

形式	Liquid
纯化	Purification with Protein G.
缓冲液	PBS (pH 7.4), 0.1% Sodium azide and 50% Glycerol.
抗菌剂	0.1% Sodium azide
稳定剂	50% Glycerol
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 25472 Rat KCNJ8 GeneID: 3764 Human KCNJ8 Swiss-port # Q15842 Human ATP-sensitive inward rectifier potassium channel 8 Swiss-port # Q63664 Rat ATP-sensitive inward rectifier potassium channel 8
基因名称	KCNJ8
全名	potassium channel, inwardly rectifying subfamily J, member 8
背景介绍	Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]
生物功能	This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). [UniProt]
细胞定位	Membrane; Multi-pass membrane protein. [UniProt]
预测分子量	48 kDa

检测图片 (2)

ARG23904 anti-KCNJ8 / kir6.1 antibody [S366-60] ICC/IF image
Immunofluorescence: Human neuroblastoma cell line SK-N-BE fixed with 4% Formaldehyde for 15 min at RT. Cells were stained with ARG23904 anti-KCNJ8 / kir6.1 antibody [S366-60] (green) at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain. Lower right picture: Composite.
ARG23904 anti-KCNJ8 / kir6.1 antibody [S366-60] WB image
Western blot: 20 µg of Rat brain lysate stained with ARG23904 anti-KCNJ8 / kir6.1 antibody [S366-60] at 1:1000 for 16 hours at 4°C.

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