anti-KDM4A / JHDM3A antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes KDM4A / JHDM3A
  • 反应物种: Hu, Ms, Rat
  • 应用: IHC-P, IP, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: KDM4A / JHDM3A
  • 抗原物种: Human
  • 抗原: Synthetic peptide derived from Human KDM4A / JHDM3A.
  • Brand:
CAT.NO. : ARG40746
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes KDM4A / JHDM3A
反应物种Hu, Ms, Rat
应用IHC-P, IP, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称KDM4A / JHDM3A
抗原物种Human
抗原Synthetic peptide derived from Human KDM4A / JHDM3A.
偶联标记Un-conjugated
別名JMJD2; Lysine-specific demethylase 4A; JMJD2A; Jumonji domain-containing protein 2A; JHDM3A; TDRD14A; EC 1.14.11.-; JmjC domain-containing histone demethylation protein 3A
应用说明
应用建议
应用推荐稀释比
IHC-P1:50 - 1:200
IP1:60
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 230674 Mouse KDM4A

GeneID: 9682 Human KDM4A

Swiss-port # O75164 Human Lysine-specific demethylase 4A

Swiss-port # Q8BW72 Mouse Lysine-specific demethylase 4A

基因名称KDM4A
全名lysine (K)-specific demethylase 4A
背景介绍This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
生物功能Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.

Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. [UniProt]
细胞定位Nucleus. [UniProt]
预测分子量121 kDa
翻译后修饰Ubiquitinated by RNF8 and RNF168 following DNA damage, leading to its degradation. Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited. [UniProt]
检测图片 (1)
  • ARG40746 anti-KDM4A / JHDM3A antibody WB image

    Western blot: HEK293 cell lysate stained with ARG40746 anti-KDM4A / JHDM3A antibody.

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