anti-KIR2DL3 antibody [190IIC311]
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Key features and details
- 产品描述:
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- 应用:
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- 克隆:
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- 同位型:
- 靶点名称:
- 抗原物种:
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CAT.NO. : ARG56909
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [190IIC311] recognizes KIR2DL3 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 190IIC311 |
| 同位型 | IgG2a, kappa |
| 靶点名称 | KIR2DL3 |
| 抗原物种 | Human |
| 抗原 | Recombinant fragment around aa. 19-161 of Human KIR2DL3. |
| 偶联标记 | Un-conjugated |
| 別名 | NKAT-2; CD158B2; p58.2 MHC class-I-specific NK receptor; CD158 antigen-like family member B2; KIR-023GB; Natural killer-associated transcript 2; KIR2DS5; GL183; Killer cell immunoglobulin-like receptor 2DL3; p58 natural killer cell receptor clone CL-6; KIR-K7b; KIR-K7c; NKAT2b; NKAT2a; p58 NK receptor CL-6; p58; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT2; NKAT2B; NKAT2A; CD antigen CD158b2; CD158b; NKAT; KIRCL23 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 10% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P43628 Human Killer cell immunoglobulin-like receptor 2DL3 |
|---|---|
| 基因名称 | KIR2DL3 |
| 全名 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 |
| 背景介绍 | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis. [UniProt] |
| 预测分子量 | 38 kDa |
检测图片 (2)
ARG56909 anti-KIR2DL3 antibody [190IIC311] ICC/IF image
Immunoflorescense: HeLa cell line stained with ARG56909 anti-KIR2DL3 antibody [190IIC311] at 1:100 (Green).
DAPI (Blue) for nucleus staining.
ARG56909 anti-KIR2DL3 antibody [190IIC311] WB image
Western blot: 50 ng of 1) KIR2DL1, 2) KIR2DL3, and 3) KIR2DS4 recombinant protein stained with ARG56909 anti-KIR2DL3 antibody [190IIC311] at 1:1000.
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