anti-KLHL25 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG42145
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes KLHL25 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Cow, Dog, Gpig, Pig, Rb |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | KLHL25 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the N-terminal region of Human KLHL25. (within the following region: RLYEF SWRMC LVHFE TVRQS EDFNS LSKDT LLDLI SSDEL ETEDE RVVFE) |
| 偶联标记 | Un-conjugated |
| 別名 | ENC-2; Kelch-like protein 25; ENC2; Ectoderm-neural cortex protein 2 |
应用说明
| 预测反应性说明 | Predicted Homology Based on Immunogen Sequence: Cow: 93%; Dog: 100%; Guinea pig: 93%; Mouse: 86%; Pig: 100%; Rabbit: 86%; Rat: 86% | ||||||
|---|---|---|---|---|---|---|---|
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Jurkat | ||||||
| 实际分子量 | ~ 67 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.09% (w/v) Sodium azide and 2% Sucrose. |
| 抗菌剂 | 0.09% (w/v) Sodium azide |
| 稳定剂 | 2% Sucrose |
| 浓度 | Batch dependent: 0.5 - 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | KLHL25 |
| 全名 | kelch-like family member 25 |
| 生物功能 | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. [UniProt] |
| 预测分子量 | 66 kDa |
检测图片 (2)
ARG42145 anti-KLHL25 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human brain tissue stained with ARG42145 anti-KLHL25 antibody.
ARG42145 anti-KLHL25 antibody WB image
Western blot: Jurkat cell lysate stained with ARG42145 anti-KLHL25 antibody at 0.3 µg/ml dilution.
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