anti-L1CAM antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG59519
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes L1CAM |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | L1CAM |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1143-1257 of Human L1CAM (NP_000416.1). |
| 偶联标记 | Un-conjugated |
| 別名 | SPG1; CD171; NCAM-L1; MASA; MIC5; S10; CAML1; HSAS1; N-CAM-L1; CD antigen CD171; N-CAML1; HSAS; Neural cell adhesion molecule L1 |
应用说明
| 预测反应性说明 | Rat | ||||||
|---|---|---|---|---|---|---|---|
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | SH-SY5Y | ||||||
| 实际分子量 | 200 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | L1CAM |
| 全名 | L1 cell adhesion molecule |
| 背景介绍 | The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013] |
| 生物功能 | Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons. [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. Cell projection, growth cone. Cell projection, axon. Cell projection, dendrite. Note=Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658). [UniProt] |
| 预测分子量 | 140 kDa |
检测图片 (2)
ARG59519 anti-L1CAM antibody WB image
Western blot: 25 µg of SH-SY5Y cell lysate stained with ARG59519 anti-L1CAM antibody at 1:1000 dilution.
ARG59519 anti-L1CAM antibody WB image
Western blot: 25 µg of extracts from normal (control) and L1CAM knockout (KO) HeLa cells, using ARG59519 anti-L1CAM antibody at 1:1000 dilution.
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