anti-LGI1 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes LGI1
  • 反应物种: Hu, Ms, Rat
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: LGI1
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 301-557 of Human LGI1 (NP_005088.1).
  • Brand:
CAT.NO. : ARG59784
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes LGI1
反应物种Hu, Ms, Rat
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称LGI1
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 301-557 of Human LGI1 (NP_005088.1).
偶联标记Un-conjugated
別名ETL1; EPT; ADPAEF; ADLTE; Epitempin-1; IB1099; Leucine-rich glioma-inactivated protein 1; ADPEAF; EPITEMPIN
应用说明
应用建议
应用推荐稀释比
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Rat brain, Mouse brain and U-87MG
实际分子量64 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 252892 Rat LGI1

GeneID: 56839 Mouse LGI1

GeneID: 9211 Human LGI1

基因名称LGI1
全名leucine-rich, glioma inactivated 1
背景介绍This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
生物功能Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. [UniProt]
细胞定位Secreted. Cell junction, synapse. Note=Isoform 1 but not isoform 2 is secreted. Isoform 1 is enriched in the Golgi apparatus while isoform 2 accumulates in the endoplasmic reticulum. [UniProt]
预测分子量64 kDa
翻译后修饰Glycosylated. [UniProt]
检测图片 (1)
  • ARG59784 anti-LGI1 antibody WB image

    Western blot: 25 µg of Rat brain, Mouse brain and U-87MG cell lysates stained with ARG59784 anti-LGI1 antibody at 1:3000 dilution.

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