anti-LGR4 / GPR48 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes LGR4 / GPR48
  • 反应物种: Hu, Ms, Rat
  • 应用: ICC/IF, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: LGR4 / GPR48
  • 抗原物种: Human
  • 抗原: Recombinant protein of Human LGR4 / GPR48.
  • Brand:
CAT.NO. : ARG56874
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes LGR4 / GPR48
反应物种Hu, Ms, Rat
应用ICC/IF, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称LGR4 / GPR48
抗原物种Human
抗原Recombinant protein of Human LGR4 / GPR48.
偶联标记Un-conjugated
別名G-protein coupled receptor 48; BNMD17; Leucine-rich repeat-containing G-protein coupled receptor 4; GPR48
应用说明
应用建议
应用推荐稀释比
ICC/IF1:50 - 1:200
WB1:1000 - 1:3000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照HeLa
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 107515 Mouse LGR4

GeneID: 286994 Rat LGR4

GeneID: 55366 Human LGR4

基因名称LGR4
全名leucine-rich repeat containing G protein-coupled receptor 4
背景介绍G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008]
生物功能Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity). [UniProt]
预测分子量104 kDa
检测图片 (1)
  • ARG56874 anti-LGR4 / GPR48 antibody WB image

    Western blot: HeLa cell lysate stained with ARG56874 anti-LGR4 / GPR48 antibody.

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