anti-LIFR antibody [12D3] (PE)
![anti-LIFR antibody [12D3] (PE)](/upload/image/products/ARG44246_210_205.jpg)
![anti-LIFR antibody [12D3] (PE)](/upload/image/products/ARG44246.jpg)
Key features and details
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CAT.NO. : ARG44246
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Product Details
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [12D3] recognizes LIFR |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 12D3 |
| 同位型 | IgG1, kappa |
| 靶点名称 | LIFR |
| 抗原物种 | Human |
| 抗原 | CD118-Fc recombinant Protein |
| 偶联标记 | PE |
| 別名 | CD118; CD antigen CD118; STWS; SJS2; LIF receptor; Leukemia inhibitory factor receptor; SWS; LIF-R |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS (pH 7.4) and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 0.1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Do not freeze. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P42702 Human Leukemia inhibitory factor receptor |
|---|---|
| 基因名称 | LIFR |
| 全名 | leukemia inhibitory factor receptor alpha |
| 背景介绍 | This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. [UniProt] |
| 细胞定位 | Isoform 1: Cell membrane; Single-pass type I membrane protein. [UniProt] |
检测图片 (1)
ARG44246 anti-LIFR antibody [12D3] (PE) FACS image
Flow Cytometry: JAR stained with ARG44246 anti-LIFR antibody [12D3] (PE) at 10 μl/ 100 μl whole blood dilution.
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