anti-LONP1 / Lon antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
Product Details
| 产品描述 | Rabbit Polyclonal antibody recognizes LONP1 / Lon |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | LONP1 / Lon |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human LONP1 / Lon. |
| 偶联标记 | Un-conjugated |
| 別名 | LONHs; Lon protease homolog, mitochondrial; Serine protease 15; PIM1; Mitochondrial ATP-dependent protease Lon; PRSS15; LON; hLON; EC 3.4.21.-; LonHS; LONP; CODASS; Lon protease-like protein |
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | IHC-P: Human breast cancer and Human esophagus cancer. WB: A431, HeLa, HepG2, Mouse liver and NIH/3T3. | ||||||
| 实际分子量 | ~ 105 kDa |
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.4), 0.05% Sodium azide and 40% Glycerol. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 40% Glycerol |
| 浓度 | 1.6 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | Swiss-port # P36776 Human Lon protease homolog, mitochondrial Swiss-port # Q8CGK3 Mouse Lon protease homolog, mitochondrial |
|---|---|
| 基因名称 | LONP1 |
| 全名 | lon peptidase 1, mitochondrial |
| 背景介绍 | This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013] |
| 生物功能 | ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein. [UniProt] |
| 细胞定位 | Mitochondrion matrix. [UniProt] |
| 预测分子量 | 106 kDa |
ARG40308 anti-LONP1 / Lon antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human breast cancer tissue stained with ARG40308 anti-LONP1 / Lon antibody (left) at 1:25 dilution, or the same antibody pre-incubated with antigen (right). (Original magnification: X200)
ARG40308 anti-LONP1 / Lon antibody WB image
Western blot: 40 µg of A431, NIH/3T3, HepG2, Mouse liver and HeLa cell lysates stained with ARG40308 anti-LONP1 / Lon antibody at 1:250 dilution.
ARG40308 anti-LONP1 / Lon antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human esophagus cancer tissue stained with ARG40308 anti-LONP1 / Lon antibody (left) at 1:25 dilution, or the same antibody pre-incubated with antigen (right). (Original magnification: X200)
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