anti-LOX antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes LOX
  • 反应物种: Hu, Ms, Rat
  • 应用: FACS, ICC/IF, IHC-P, IP, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: LOX
  • 抗原物种: Human
  • 抗原: Synthetic peptide of Human LOX.
  • Brand:
CAT.NO. : ARG41539
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes LOX
反应物种Hu, Ms, Rat
应用FACS, ICC/IF, IHC-P, IP, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称LOX
抗原物种Human
抗原Synthetic peptide of Human LOX.
偶联标记Un-conjugated
別名Lysyl oxidase; EC 1.4.3.13; Protein-lysine 6-oxidase
应用说明
应用建议
应用推荐稀释比
FACS1:60
ICC/IF1:50 - 1:200
IHC-P1:50 - 1:200
IP1:50
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Jurkat
实际分子量~ 50 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 24914 Rat LOX

GeneID: 4015 Human LOX

Swiss-port # P16636 Rat Protein-lysine 6-oxidase

Swiss-port # P28300 Human Protein-lysine 6-oxidase

基因名称LOX
全名lysyl oxidase
背景介绍The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
生物功能Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. [UniProt]
细胞定位Secreted. Secreted, extracellular space. [UniProt]
预测分子量47 kDa
翻译后修饰The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Proteolytically activated by BMP1. [UniProt]
检测图片 (3)
  • ARG41539 anti-LOX antibody ICC/IF image

    Immunofluorescence: Jurkat cells stained with ARG41539 anti-LOX antibody (green).

  • ARG41539 anti-LOX antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human breast tissue stained with ARG41539 anti-LOX antibody.

  • ARG41539 anti-LOX antibody WB image

    Western blot: Jurkat cell lysate stained with ARG41539 anti-LOX antibody.

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