anti-Lrp2 / Megalin antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes Lrp2 / Megalin
  • 反应物种: Ms, Rat
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: Lrp2 / Megalin
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 4446-4655 of Human Lrp2 (NP_004516.2).
  • Brand:
CAT.NO. : ARG40332
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes Lrp2 / Megalin
反应物种Ms, Rat
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称Lrp2 / Megalin
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 4446-4655 of Human Lrp2 (NP_004516.2).
偶联标记Un-conjugated
別名GP330; gp330; Glycoprotein 330; LRP-2; Megalin; Low-density lipoprotein receptor-related protein 2; DBS
应用说明
应用建议
应用推荐稀释比
IHC-P1:50 - 1:200
WB1:200 - 1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 14725 Mouse LRP2

GeneID: 29216 Rat LRP2

Swiss-port # A2ARV4 Mouse Low-density lipoprotein receptor-related protein 2

Swiss-port # P98158 Rat Low-density lipoprotein receptor-related protein 2

基因名称LRP2
全名low density lipoprotein receptor-related protein 2
背景介绍The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
生物功能Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release. [UniProt]
细胞定位Apical cell membrane; Single-pass type I membrane protein. Endosome lumen. Membrane, coated pit. Cell projection, dendrite. Cell projection, axon. Note=Localizes to brush border membranes in the kidney. In the endolymphatic sac of the inner ear, located in the lumen of endosomes as a soluble form. [UniProt]
预测分子量522 kDa
检测图片 (1)
  • ARG40332 anti-Lrp2 / Megalin antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Rat kidney stained with ARG40332 anti-Lrp2 / Megalin antibody at 1:100 dilution.

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