anti-LRPPRC antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG56278
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes LRPPRC |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | LRPPRC |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human LRPPRC |
| 偶联标记 | Un-conjugated |
| 別名 | CLONE-23970; LRP 130; GP130; 130 kDa leucine-rich protein; LSFC; LRP130; Leucine-rich PPR motif-containing protein, mitochondrial |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | LRPPRC |
| 全名 | leucine-rich pentatricopeptide repeat containing |
| 背景介绍 | This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012] |
| 生物功能 | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). [UniProt] |
| 预测分子量 | 158 kDa |
检测图片 (3)
ARG56278 anti-LRPPRC antibody WB image
Western blot: 30 µg of 293T and HCT116 cell lysates stained with ARG56278 anti-LRPPRC antibody at 1:1000 dilution.
ARG56278 anti-LRPPRC antibody WB image
Western blot: 30 µg of HepG2 and HCT116 cell lysates stained with ARG56278 anti-LRPPRC antibody at 1:1000 dilution.
ARG56278 anti-LRPPRC antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver stained with ARG56278 anti-LRPPRC antibody at 1:100 dilution.
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