anti-MAP3K3 / MEKK3 antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG43172
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MAP3K3 / MEKK3 |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MAP3K3 / MEKK3 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human MAP3K3 / MEKK3. |
| 偶联标记 | Un-conjugated |
| 別名 | MAPK/ERK kinase kinase 3; MEK kinase 3; EC 2.7.11.25; Mitogen-activated protein kinase kinase kinase 3; MEKK3; MEKK 3; MAPKKK3 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | HeLa | ||||||||
| 实际分子量 | ~ 70 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q61084 Mouse Mitogen-activated protein kinase kinase kinase 3 Swiss-port # Q99759 Human Mitogen-activated protein kinase kinase kinase 3 |
|---|---|
| 基因名称 | MAP3K3 |
| 全名 | mitogen-activated protein kinase kinase kinase 3 |
| 背景介绍 | This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| 生物功能 | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. [UniProt] |
| 预测分子量 | 71 kDa |
| 翻译后修饰 | Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity. [UniProt] |
检测图片 (1)
ARG43172 anti-MAP3K3 / MEKK3 antibody WB image
Western blot: HeLa cell lysate stained with ARG43172 anti-MAP3K3 / MEKK3 antibody.
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