anti-Mast Cell Tryptase antibody [AA1]
![anti-Mast Cell Tryptase antibody [AA1]](/upload/image/products/ARG22511_IHC-P_1_210_205.jpg)
![anti-Mast Cell Tryptase antibody [AA1]](/upload/image/products/ARG22511_IHC-P_1.jpg)
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CAT.NO. : ARG22511
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [AA1] recognizes Mast Cell Tryptase This antibody recognizes human mast cell tryptase, both alpha and beta isoforms. Mouse anti Mast cel tryptase, clone AA1 is an excellent marker for mast cells, and does not bind to any other cell type in immunohistology (Walls et al. 1990).Tryptases are the products of a number of genes and form the major neutral protease present in mast cells secreted in response to infection and injury. Mast cell tryptase has an important role in the pathology of inflammatory diseases, especially asthma through bronchoconstriction (Zhang and Timmerman 1997). |
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| 反应物种 | Hu, Rat, Cat, Dog, Mk |
| 应用 | ELISA, ICC/IF, IHC-Fr, IHC-P |
| 特异性 | This antibody recognizes human mast cell tryptase, both alpha and beta isoforms. Including protein Tryptase alpha/beta-1 (TPSAB1) and Tryptase beta-2 (TPSB2). |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | AA1 |
| 同位型 | IgG1 |
| 靶点名称 | Mast Cell Tryptase |
| 抗原物种 | Human |
| 抗原 | Human mast cell tryptase purified from human lung tissue. |
| 偶联标记 | Un-conjugated |
| 別名 | tryptaseC; tryptaseB; Tryptase beta-2; TPS2; Tryptase II; EC 3.4.21.59; Tryptase-2; TPS1, TPS2, TPSB1 |
应用说明
| 应用建议 |
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| 应用说明 | IHC-P: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | TPSAB1 + TPSB2 |
|---|---|
| 全名 | Tryptase alpha/beta-1 + tryptase beta 2 (gene/pseudogene) |
| 背景介绍 | Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008] |
| 生物功能 | Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. [UniProt] |
| 预测分子量 | 31 kDa |
检测图片 (1)
ARG22511 anti-Mast Cell Tryptase antibody [AA1] IHC-P image
Immunohistochemistry: Paraffin-embedded Human tonsil stained with ARG22511 anti-Mast Cell Tryptase antibody [AA1].
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