anti-MBTPS1 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG56137
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MBTPS1 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MBTPS1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 803-1052 of Human MBTPS1 (NP_003782.1). |
| 偶联标记 | Un-conjugated |
| 別名 | PCSK8; Endopeptidase S1P; EC 3.4.21.112; S1P; Membrane-bound transcription factor site-1 protease; SKI-1; Subtilisin/kexin-isozyme 1 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | K562 and Mouse pancreas | ||||
| 实际分子量 | ~ 110 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q14703 Human Membrane-bound transcription factor site-1 protease Swiss-port # Q9WTZ2 Mouse Membrane-bound transcription factor site-1 protease |
|---|---|
| 基因名称 | MBTPS1 |
| 全名 | membrane-bound transcription factor peptidase, site 1 |
| 背景介绍 | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014] |
| 生物功能 | Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. [UniProt] |
| 预测分子量 | 118 kDa |
| 翻译后修饰 | The 148 kDa zymogen is processed progressively into two membrane-bound 120 and 106 kDa forms in the endoplasmic reticulum, and late into a secreted 98 kDa form. The propeptide is autocatalytically removed through an intramolecular cleavage after Leu-186. Further cleavage generates 14, 10, and 8 kDa intermediates. |
检测图片 (2)
ARG56137 anti-MBTPS1 antibody WB image
Western blot: 25 µg of K562 cell lysate stained with ARG56137 anti-MBTPS1 antibody at 1:1000 dilution.
ARG56137 anti-MBTPS1 antibody WB image
Western blot: 25 µg of Mouse pancreas lysate stained with ARG56137 anti-MBTPS1 antibody at 1:1000 dilution.
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