anti-MCM4 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG40437
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MCM4 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MCM4 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human MCM4. |
| 偶联标记 | Un-conjugated |
| 別名 | NKCD; P1-CDC21; hCdc21; DNA replication licensing factor MCM4; NKGCD; CDC21; CDC21 homolog; EC 3.6.4.12; CDC54 |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P33991 Human DNA replication licensing factor MCM4 Swiss-port # P49717 Mouse DNA replication licensing factor MCM4 |
|---|---|
| 基因名称 | MCM4 |
| 全名 | minichromosome maintenance complex component 4 |
| 背景介绍 | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] |
| 生物功能 | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 97 kDa |
| 翻译后修饰 | Sumoylated; SUMO2 modified in response to stress caused by inhibition of proteasome activity (in vitro). [UniProt] |
检测图片 (1)
ARG40437 anti-MCM4 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse brain stained with ARG40437 anti-MCM4 antibody at 1:200 dilution.
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