anti-MCM4 phospho (Ser54) antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
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- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG66544
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MCM4 phospho (Ser54) |
|---|---|
| 反应物种 | Hu, Ms, Mk |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MCM4 |
| 抗原物种 | Human |
| 抗原 | Phosphospecific peptide around Ser54 of Human MCM4. |
| 偶联标记 | Un-conjugated |
| 別名 | DHP; DPD; DHPDHASE; Dihydropyrimidine dehydrogenase [NADP(+)]; DHPDHase; DPD; EC 1.3.1.2; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: High-pressure and temperature Tris-EDTA buffer (pH 8.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.5% BSA |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q12882 Human Dihydropyrimidine dehydrogenase [NADP(+)] Swiss-port # Q8CHR6 Mouse Dihydropyrimidine dehydrogenase [NADP(+)] |
|---|---|
| 基因名称 | DPYD |
| 全名 | dihydropyrimidine dehydrogenase |
| 背景介绍 | The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
| 生物功能 | Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 111 kDa |
检测图片 (2)
ARG66544 anti-MCM4 phospho (Ser54) antibody WB image
Western blot: COS7 cells treated with nocodazole (1 µg/ml, 16 hours) and stained with ARG66544 anti-MCM4 phospho (Ser54) antibody. The lane on the right was blocked with the phospho peptide.
ARG66544 anti-MCM4 phospho (Ser54) antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human brain tissue stained with ARG66544 anti-MCM4 phospho (Ser54) antibody at 1:100, 4°C and overnight. Antigen Retrieval: High-pressure and temperature Tris-EDTA buffer (pH 8.0). The picture on the right was blocked with the synthetic peptide.
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