anti-MCM6 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes MCM6
  • 反应物种: Hu, Ms, Rat
  • 应用: FACS, ICC/IF, IHC-P, IP, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: MCM6
  • 抗原物种: Human
  • 抗原: Recombinant protein of Human MCM6.
  • Brand:
CAT.NO. : ARG40433
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes MCM6
反应物种Hu, Ms, Rat
应用FACS, ICC/IF, IHC-P, IP, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称MCM6
抗原物种Human
抗原Recombinant protein of Human MCM6.
偶联标记Un-conjugated
別名p105MCM; P105MCM; DNA replication licensing factor MCM6; MCG40308; EC 3.6.4.12; Mis5
应用说明
应用建议
应用推荐稀释比
FACS1:20
ICC/IF1:50
IHC-P1:500
IP1:20
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purified.
缓冲液50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA.
抗菌剂0.01% Sodium azide
稳定剂40% Glycerol and 0.05% BSA
浓度Batch dependent
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 17219 Mouse MCM6

GeneID: 4175 Human MCM6

Swiss-port # P97311 Mouse DNA replication licensing factor MCM6

Swiss-port # Q14566 Human DNA replication licensing factor MCM6

基因名称MCM6
全名minichromosome maintenance complex component 6
背景介绍The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]
生物功能Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. [UniProt]
细胞定位Nucleus. Note=Binds to chromatin during G1 and detach from it during S phase. [UniProt]
预测分子量93 kDa
翻译后修饰O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. [UniProt]
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