anti-mGluR1 + mGluR5 antibody [S75-33]
![anti-mGluR1 + mGluR5 antibody [S75-33]](/upload/image/products/ARG22244_1_210_205.jpg)
![anti-mGluR1 + mGluR5 antibody [S75-33]](/upload/image/products/ARG22244_1.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
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Brand:
CAT.NO. : ARG22244
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Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [S75-33] recognizes mGluR1 + mGluR5 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC, IP, WB |
| 特异性 | Detects ~130kDa (both mGluR1 and mGluR5). |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | S75-33 |
| 同位型 | IgG1 |
| 靶点名称 | mGluR1 + mGluR5 |
| 抗原物种 | Rat |
| 抗原 | Fusion protein around aa. 824-1203 (cytoplasmic C-terminus) of Rat mGluR5b |
| 偶联标记 | Un-conjugated |
| 別名 | PPP1R86; mGlu5; GPRC1E; Metabotropic glutamate receptor 5; mGluR5; MGLUR5 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Grm5 |
| 全名 | glutamate receptor, metabotropic 5 |
| 背景介绍 | This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| 生物功能 | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. [UniProt] |
| 细胞定位 | Cell membrane |
| 预测分子量 | ~130 kDa (both mGluR1 and mGluR5). |
检测图片 (1)
ARG22244 anti-mGluR1 + mGluR5 antibody [S75-33] WB image
Western blot: Rat brain membrane lysate stained with ARG22244 anti-mGluR1 + mGluR5 antibody [S75-33] at 1:1000 dilution.
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