anti-MNK2B antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes MNK2B
  • 反应物种: Hu
  • 预测物种: NHuPrm
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: MNK2B
  • 抗原物种: Human
  • Brand:
CAT.NO. : ARG44280
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes MNK2B
反应物种Hu
预测物种NHuPrm
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称MNK2B
抗原物种Human
抗原MNK2B Synthetic peptide
偶联标记Un-conjugated
別名MKNK2; MAPK Interacting Serine/Threonine Kinase 2; MNK2; GPRK7; MAP Kinase-Interacting Serine/Threonine-Protein Kinase 2; MAP Kinase Interacting Serine/Threonine Kinase 2; MAP Kinase Signal-Integrating Kinase 2; G Protein-Coupled Receptor Kinase 7; MAPK Signal-Integrating Kinase 2; EC 2.7.11.1; Putative Map Kinase Interacting Kinase; EC 2.7.11,; Mnk2
应用说明
应用建议
应用推荐稀释比
WB1:1000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Antigen Affinity Purified
缓冲液10 mM HEPES (pH 7.5), 150 mM NaCl, 50% Glycerol and 100 µg/ml BSA.
稳定剂50% Glycerol and 100 µg/ml BSA
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
生物信息
数据库连接

GeneID: 2872 Human MKNK2

Swiss-port # Q9HBH9 Human MAP kinase-interacting serine/threonine-protein kinase 2

基因名称MKNK2
全名MAPK Interacting Serine/Threonine Kinase 2
背景介绍This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization.
生物功能Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As2O3-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
细胞定位Cytoplasm, Nucleus
预测分子量47 kDa
翻译后修饰Phosphoprotein
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