anti-MRP2 antibody
Key features and details
- 产品描述:
- 反应物种:
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- 克隆:
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- 靶点名称:
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- 抗原:
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Brand:
CAT.NO. : ARG58445
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes MRP2 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | MRP2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human MRP2. |
| 偶联标记 | Un-conjugated |
| 別名 | DJS; ATP-binding cassette sub-family C member 2; CMOAT; ABC30; cMRP; Canalicular multidrug resistance protein; MRP2; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2 |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | HepG2 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q92887 Human Canalicular multispecific organic anion transporter 1 |
|---|---|
| 基因名称 | ABCC2 |
| 全名 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
| 背景介绍 | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008] |
| 生物功能 | Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. [UniProt] |
| 细胞定位 | Apical cell membrane > Multi-pass membrane protein. [UniProt] |
| 预测分子量 | 174 kDa |
检测图片 (1)
ARG58445 anti-MRP2 antibody WB image
Western blot: HepG2 cell lysate stained with ARG58445 anti-MRP2 antibody.
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