anti-MTH1 antibody [3B3]
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Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
Product Details
| 产品描述 | Mouse Monoclonal antibody [3B3] recognizes MTH1 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 3B3 |
| 同位型 | IgG1, kappa |
| 靶点名称 | MTH1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fragment around aa. 1-156 of Human MTH1 |
| 偶联标记 | Un-conjugated |
| 別名 | 8-oxo-dGTPase; MTH1; EC 3.6.1.56; EC 3.6.1.55; 7,8-dihydro-8-oxoguanine triphosphatase; Nudix motif 1; 2-hydroxy-dATP diphosphatase; Nucleoside diphosphate-linked moiety X motif 1 |
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 10% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | Swiss-port # P36639 Human 7,8-dihydro-8-oxoguanine triphosphatase |
|---|---|
| 基因名称 | NUDT1 |
| 全名 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 |
| 背景介绍 | Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008] |
| 生物功能 | Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. [UniProt] |
| 预测分子量 | 23 kDa |
| 翻译后修饰 | The N-terminus is blocked. |
ARG57149 anti-MTH1 antibody [3B3] FACS image
Flow Cytometry: Jurkat cell line stained with ARG57149 anti-MTH1 antibody [3B3] at 2-5 µg for 1x10^6 cells (red line). Secondary antibody: Goat anti-Mouse IgG Alexa fluor 488 conjugate. Isotype control antibody: Mouse IgG (black line).
ARG57149 anti-MTH1 antibody [3B3] WB image
Western blot: 40 µg of 1) K-562, 2) SW480, 3) THP-1, 4) Jurkat, and 5) A549 cell lysates stained with ARG57149 anti-MTH1 antibody [3B3] at 1:500.
ARG57149 anti-MTH1 antibody [3B3] FACS image
Flow Cytometry: SW480 cell line stained with ARG57149 anti-MTH1 antibody [3B3] at 2-5 µg for 1x10^6 cells (red line). Secondary antibody: Goat anti-Mouse IgG Alexa fluor 488 conjugate. Isotype control antibody: Mouse IgG (black line).
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