anti-MyD88 (L265P mutation) antibody [SQab30311]
![anti-MyD88 (L265P mutation) antibody [SQab30311]](/upload/image/products/ARG67041_PN_210_205.jpg)
![anti-MyD88 (L265P mutation) antibody [SQab30311]](/upload/image/products/ARG67041_PN.jpg)
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CAT.NO. : ARG67041
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Product Details
概述
| 产品描述 | Recombinant rabbit Monoclonal antibody [SQab30311] recognizes MyD88 (L265P mutation) |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 特异性 | This antibody is specifically for detects MyD88 L265P mutation |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30311 |
| 同位型 | IgG |
| 靶点名称 | MyD88 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human MyD88 (L265P mutation). |
| 偶联标记 | Un-conjugated |
| Protein Full name | Myeloid differentiation primary response protein MyD88 (L265P mutation) |
| 別名 | MYD88, MYD88 Innate Immune Signal Transduction Adaptor, Myeloid Differentiation Primary Response Protein MyD88, Myeloid Differentiation Primary Response Gene (88), Myeloid Differentiation Primary Response 88, TLR Adaptor MYD88, Mutant Myeloid Differentiation Primary Response 88, MYD88D, IMD68 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | Antigen Retrieval: High temperature and normal pressure mediated was performed using Tris/EDTA buffer pH 9.0 for 15 min. Primary Incubation: Room Temperature for 30 min *The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HEK293 (infected with MYD88 L265P ) |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05%BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q99836 Human Myeloid differentiation primary response protein MyD88 |
|---|---|
| 基因名称 | MyD88 |
| 全名 | MYD88 Innate Immune Signal Transduction Adaptor |
| 背景介绍 | This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
| 生物功能 | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation. [Uniprot] |
| 预测分子量 | 33 kDa |
| 翻译后修饰 | Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88. [UniProt] |
检测图片 (1)
ARG67041 anti-MyD88 (L265P mutation) antibody [SQab30311] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded HEK293 with L265P mutation (left) and no mutation (right) stained with ARG67041 anti-MyD88 (L265P mutation) antibody [SQab30311] at 1:200 dilution.
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