anti-Myelin Proteolipid Protein antibody [plpc1]

产品描述: Mouse Monoclonal antibody [plpc1] recognizes Myelin Proteolipid ProteinThis antibody recognizes myelin proteolipid protein (PLP) in many mammalian species (Stoffel et al. 1985). Clone plpc1 also recognizes the alternative PLP splice variant lacking part of the cytoplasmic domain (amino acids 117-151), known as DM20 (Simons et al. 1987) .PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease (Hudson et al. 1989).Mouse anti myelin proteolipid protein, clone plpc1 has proved a useful immunohistochemical tool for the study of central nervous system injury in patients with multiple sclerosis (Seewan et al. 2011, Huizinga et al. 2011)
反应物种: Hu, Ms, Rat, Bov
预测物种: Rb
应用: FACS, ICC/IF, IHC-Fr, IHC-P, WB
宿主: Mouse
克隆: Monoclonal
克隆号: plpc1
同位型: IgG2a
靶点名称: Myelin Proteolipid Protein

CAT.NO. : ARG22612

US＄ Please choose

Size:

50 μg

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

概述

产品描述	Mouse Monoclonal antibody [plpc1] recognizes Myelin Proteolipid Protein This antibody recognizes myelin proteolipid protein (PLP) in many mammalian species (Stoffel et al. 1985). Clone plpc1 also recognizes the alternative PLP splice variant lacking part of the cytoplasmic domain (amino acids 117-151), known as DM20 (Simons et al. 1987) .PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease (Hudson et al. 1989).Mouse anti myelin proteolipid protein, clone plpc1 has proved a useful immunohistochemical tool for the study of central nervous system injury in patients with multiple sclerosis (Seewan et al. 2011, Huizinga et al. 2011)
反应物种	Hu, Ms, Rat, Bov
预测物种	Rb
应用	FACS, ICC/IF, IHC-Fr, IHC-P, WB
宿主	Mouse
克隆	Monoclonal
克隆号	plpc1
同位型	IgG2a
靶点名称	Myelin Proteolipid Protein
抗原物种	Bovine
抗原	Synthetic peptide GRGTKF corresponding to C terminal region of myelin proteolipid protein.
偶联标记	Un-conjugated
別名	MMPL; PLP; SPG2; PMD; Myelin proteolipid protein; GPM6C; Lipophilin; PLP/DM20; HLD1

应用说明

应用建议

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein A.
缓冲液	PBS and 0.09% Sodium azide
抗菌剂	0.09% Sodium azide
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 18823 Mouse PLP1 GeneID: 24943 Rat PLP1 GeneID: 281410 Bovine PLP1 GeneID: 5354 Human PLP1 Swiss-port # P04116 Bovine Myelin proteolipid protein Swiss-port # P60201 Human Myelin proteolipid protein Swiss-port # P60202 Mouse Myelin proteolipid protein Swiss-port # P60203 Rat Myelin proteolipid protein More
基因名称	PLP1
全名	proteolipid protein 1
背景介绍	This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]
生物功能	This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. [UniProt]
预测分子量	30 kDa

New Products