anti-N-Ras antibody
CAT.NO. : ARG55671
US$ Please choose
US$ Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整,请以品牌方官网实时更新的价格为准,以确保准确性。
概述
产品描述 | Mouse Monoclonal antibody recognizes N-Ras |
---|---|
反应物种 | Hu, Rat |
应用 | WB |
宿主 | Mouse |
克隆 | Monoclonal |
克隆号 | 822CT17.5.1 |
同位型 | IgG1 |
靶点名称 | N-Ras |
抗原物种 | Human |
抗原 | KLH-conjugated synthetic peptide corresponding to aa. 70-101 of Human N-Ras. |
偶联标记 | Un-conjugated |
別名 | GTPase NRas; N-ras; NRAS1; CMNS; Transforming protein N-Ras; NCMS; ALPS4; NS6 |
应用说明
应用建议 |
| ||||
---|---|---|---|---|---|
应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
阳性对照 | A431 |
属性
形式 | Liquid |
---|---|
纯化 | Purification with Protein G. |
缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
抗菌剂 | 0.09% (W/V) Sodium azide. |
存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
数据库连接 | |
---|---|
基因名称 | NRAS |
全名 | neuroblastoma RAS viral (v-ras) oncogene homolog |
背景介绍 | This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011] |
生物功能 | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. [UniProt] |
细胞定位 | Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the plasma membrane and the Golgi apparatus |
预测分子量 | 21 kDa |
翻译后修饰 | Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi. Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs). |
