anti-NAB2 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes NAB2
  • 反应物种: Hu, Ms
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: NAB2
  • 抗原物种: Human
  • 抗原: KLH-conjugated synthetic peptide encompassing a sequence within the center region of Human NAB2.
  • Brand:
CAT.NO. : ARG66550
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes NAB2
反应物种Hu, Ms
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称NAB2
抗原物种Human
抗原KLH-conjugated synthetic peptide encompassing a sequence within the center region of Human NAB2.
偶联标记Un-conjugated
別名EGR-1-binding protein 2; MADER; Protein MADER; Melanoma-associated delayed early response protein; NGFI-A-binding protein 2
应用说明
应用建议
应用推荐稀释比
IHC-P1:100 - 1:200
WB1:500 - 1:1000
应用说明IHC-P: Antigen Retrieval: Heat mediation was performed in Sodium citrate buffer (pH 6.0).
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量57 kDa
属性
形式Liquid
纯化Affinity purification with immunogen.
缓冲液0.42% Potassium phosphate (pH 7.3), 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol.
抗菌剂0.01% Sodium azide
稳定剂30% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 17937 Mouse NAB2

GeneID: 4665 Human NAB2

Swiss-port # Q15742 Human NGFI-A-binding protein 2

Swiss-port # Q61127 Mouse NGFI-A-binding protein 2

基因名称NAB2
全名NGFI-A binding protein 2 (EGR1 binding protein 2)
背景介绍This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
生物功能Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity). [UniProt]
细胞定位Nucleus. Note=Isoform 2 is not localized to the nucleus. [UniProt]
预测分子量57 kDa
翻译后修饰Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain. [UniProt]
检测图片 (2)
  • ARG66550 anti-NAB2 antibody IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded Human breast cancer tissue. Antigen Retrieval: Heat mediation was performed in Sodium citrate buffer (pH 6.0). The section was then stained with ARG66550 anti-NAB2 antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

  • ARG66550 anti-NAB2 antibody WB image

    Western blot: HepG2, HeLa and Raw264.7 whole cell lysates stained with ARG66550 anti-NAB2 antibody.

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