anti-NAT8L antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG42231
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Product Details
概述
| 产品描述 | Goat Polyclonal antibody recognizes NAT8L |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Cow, Rat, Dog |
| 应用 | FACS, ICC/IF |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NAT8L |
| 抗原物种 | Mouse |
| 抗原 | Synthetic peptide around the internal region of Mouse NAT8L. (C-SVDSRFRGKGIAK) (NP_001001985.3) |
| 偶联标记 | Un-conjugated |
| 別名 | NAT8-LIKE; N-acetyltransferase 8-like protein; NACED; Camello-like protein 3; NAA synthetase; EC 2.3.1.17; CML3; N-acetylaspartate synthetase |
应用说明
| 应用建议 |
| ||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Ammonium sulphate precipitation followed by affinity purification with immunogen. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NAT8L |
| 全名 | N-acetyltransferase 8-like (GCN5-related, putative) |
| 背景介绍 | This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010] |
| 生物功能 | Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. [UniProt] |
| 细胞定位 | Cytoplasm. Membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane; Single-pass membrane protein. Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment. [UniProt] |
| 预测分子量 | 33 kDa |
检测图片 (2)
ARG42231 anti-NAT8L antibody ICC/IF image
Immunofluorescence: Paraformaldehyde-fixed HEK293 cells, permeabilized with 0.15% Triton. Cells were stained with ARG42231 anti-NAT8L antibody (green) at 10 µg/ml dilution for 1 hour. DAPI (blue) for nuclear staining. Negative control: Unimmunized Goat IgG at 10 µg/ml dilution.
ARG42231 anti-NAT8L antibody FACS image
Flow Cytometry: Paraformaldehyde-fixed Kelly cells, permeabilized with 0.5% Triton. Cells were stained with ARG42231 anti-NAT8L antibody (blue line) at 10 µg/ml dilution for 1 hour, followed by incubation with Alexa Fluor® 488 labelled secondary antibody. IgG control: Unimmunized Goat IgG (black line) followed by Alexa Fluor® 488 secondary antibody.
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