anti-Natriuretic Peptide Receptor A antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
Product Details
| 产品描述 | Rabbit Polyclonal antibody recognizes Natriuretic Peptide Receptor A |
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| 反应物种 | Hu, Ms, Rat |
| 应用 | Confocal, Dot, ELISA, ICC/IF, IHC, IHC-Wmt, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Natriuretic Peptide Receptor A |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around aa. 1042-1057 of Human Natriuretic Peptide Receptor A. (VRTYWLLGERGCSTRG) |
| 偶联标记 | Un-conjugated |
| 別名 | ANPa; GUCY2A; GC-A; ANPRA; Atrial natriuretic peptide receptor 1; Guanylate cyclase A; NPR-A; NPRA; GUC2A; Atrial natriuretic peptide receptor type A; EC 4.6.1.2; ANP-A; ANPR-A |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
| 形式 | Liquid |
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| 纯化 | Affinity purified. |
| 缓冲液 | Tris-Glycine Buffer (pH 7.4 - 7.8), Hepes, 0.02% Sodium azide, 30% Glycerol and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 30% Glycerol and 0.5% BSA |
| 浓度 | 0.75 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 数据库连接 | |
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| 基因名称 | NPR1 |
| 全名 | natriuretic peptide receptor 1 |
| 背景介绍 | Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009] |
| 生物功能 | Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. [UniProt] |
| 预测分子量 | 119 kDa |
| 翻译后修饰 | Phosphorylation of the protein kinase-like domain is required for full activation by ANP. |
ARG10813 anti-Natriuretic Peptide Receptor A antibody IHC image
Immunohistochemistry: Thin section of Mouse kidney tissue stained with ARG10813 anti-Natriuretic Peptide Receptor A antibody (red). Blue: Nuclei.
ARG10813 anti-Natriuretic Peptide Receptor A antibody WB image
Western blot: Recombinant Natriuretic Peptide Receptor A protein stained with ARG10813 anti-Natriuretic Peptide Receptor A antibody at 1:500 dilution.
ARG10813 anti-Natriuretic Peptide Receptor A antibody IHC image
Immunohistochemistry: Thin section of Mouse heart tissue stained with ARG10813 anti-Natriuretic Peptide Receptor A antibody (red). Blue: Nuclei.
ARG10813 anti-Natriuretic Peptide Receptor A antibody IHC-Wmt image
Immunohistochemistry: Whole-mount Mouse nose stained with ARG10813 anti-Natriuretic Peptide Receptor A antibody (red). Green: Grueneberg ganglion neurons. Blue: Nuclei.
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