anti-NCSTN / Nicastrin antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes NCSTN / Nicastrin
  • 反应物种: Hu, Ms, Rat
  • 应用: ICC/IF, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: NCSTN / Nicastrin
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 429-669 of Human NCSTN (NP_056146.1).
  • Brand:
CAT.NO. : ARG40091
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes NCSTN / Nicastrin
反应物种Hu, Ms, Rat
应用ICC/IF, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称NCSTN / Nicastrin
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 429-669 of Human NCSTN (NP_056146.1).
偶联标记Un-conjugated
別名ATAG1874; Nicastrin
应用说明
应用建议
应用推荐稀释比
ICC/IF1:50 - 1:200
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照Rat spleen and Mouse brain
实际分子量110 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 23385 Human NCSTN

GeneID: 289231 Rat NCSTN

GeneID: 59287 Mouse NCSTN

基因名称NCSTN
全名nicastrin
背景介绍This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
生物功能Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. [UniProt]
细胞定位Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. [UniProt]
预测分子量78 kDa
翻译后修饰N-glycosylated. [UniProt]
检测图片 (1)
  • ARG40091 anti-NCSTN / Nicastrin antibody WB image

    Western blot: 25 µg of Rat spleen and Mouse brain lysates stained with ARG40091 anti-NCSTN / Nicastrin antibody at 1:1000 dilution.

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