anti-NDR1 phospho (Thr444) + NDR2 phospho (Thr442) antibody
Key features and details
- 产品描述:
- 反应物种:
- 预测物种:
- 应用:
- 宿主:
- 克隆:
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- 靶点名称:
- 抗原物种:
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Brand:
CAT.NO. : ARG43419
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NDR1 phospho (Thr444) + NDR2 phospho (Thr442) |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NDR1 + NDR2 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated phosphospecific peptide around Thr444 of Human NDR1 or around Thr442 of Human NDR2. |
| 偶联标记 | Un-conjugated |
| 別名 | NDR1: Nuclear Dbf2-related kinase 1; NDR1 protein kinase; Serine/threonine-protein kinase 38; EC 2.7.11.1; NDR NDR2: Serine/threonine-protein kinase 38-like; EC 2.7.11.1; Nuclear Dbf2-related kinase 2; NDR2 protein kinase |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HepG2 + EGF | ||||
| 实际分子量 | ~ 54 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with phospho-specific peptide and the non-phospho specific antibodies were removed by chromatography using non-phosphopeptide. |
| 缓冲液 | PBS (pH 7.4, without Mg2+ and Ca2+), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | STK38; STK38L |
|---|---|
| 全名 | serine/threonine kinase 38 serine/threonine kinase 38 like |
| 背景介绍 | NDR1: This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] |
| 生物功能 | NDR1: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. [UniProt] NDR2: Involved in the regulation of structural processes in differentiating and mature neuronal cells. [UniProt] |
| 细胞定位 | NDR1: Nucleus. Cytoplasm. [UniProt] NDR2: Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Note=Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane. [UniProt] |
| 预测分子量 | NDR1 and NDR2: 54 kDa |
| 翻译后修饰 | NDR1: ISGylated; Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B. [UniProt] |
检测图片 (1)
ARG43419 anti-NDR1 phospho (Thr444) + NDR2 phospho (Thr442) antibody WB image
Western blot: EGF treated HepG2 whole cell lysate stained with ARG43419 anti-NDR1 phospho (Thr444) + NDR2 phospho (Thr442) antibody.
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