anti-Neurofilament NF-L antibody [NR-4]

Key features and details

  • 产品描述: Mouse Monoclonal antibody [NR-4] recognizes Neurofilament NF-L
  • 反应物种: Hu, Rat
  • 应用: FACS, ICC/IF, IHC-P
  • 宿主: Mouse
  • 克隆: Monoclonal
  • 克隆号: NR-4
  • 同位型: IgG1
  • 靶点名称: Neurofilament NF-L
  • 抗原物种: Pig
  • Brand:
CAT.NO. : ARG56066
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Product Details
概述
产品描述Mouse Monoclonal antibody [NR-4] recognizes Neurofilament NF-L
反应物种Hu, Rat
应用FACS, ICC/IF, IHC-P
宿主Mouse
克隆Monoclonal
克隆号NR-4
同位型IgG1
靶点名称Neurofilament NF-L
抗原物种Pig
抗原Crude neurofilament preparation from Pig spinal cord.
偶联标记Un-conjugated
別名Neurofilament triplet L protein; 68 kDa neurofilament protein; CMT1F; NF68; NFL; CMT2E; Neurofilament light polypeptide; NF-L; PPP1R110
应用说明
应用建议
应用推荐稀释比
FACS1 - 2 µg/10^6 cells
ICC/IF1 - 2 µg/ml
IHC-P0.5 - 1 µg/ml
应用说明IHC-P: Antigen Retrieval: Boil tissue section in 10 mM Citrate buffer (pH 6.0) for 10-20 min, followed by cooling at RT for 20 min.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Purification with Protein G.
缓冲液PBS (pH 7.4), 0.05% Sodium azide and 0.1 mg/ml BSA
抗菌剂0.05% Sodium azide
稳定剂0.1 mg/ml BSA
浓度0.2 mg/ml
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 4747 Human NEFL

GeneID: 83613 Rat NEFL

Swiss-port # P07196 Human Neurofilament light polypeptide

Swiss-port # P19527 Rat Neurofilament light polypeptide

基因名称NEFL
全名neurofilament, light polypeptide
背景介绍Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
生物功能Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. [UniProt]
细胞定位Cytoplasmic
产品亮点Related products:
Neurofilament NF L antibodies; Neurofilament NF L Duos / Panels; Anti-Mouse IgG secondary antibodies;
Related news:
Neuronal Development Marker
研究领域Controls and Markers antibody; Developmental Biology antibody; Neuroscience antibody; Signaling Transduction antibody; Neuronal Cytoskeletal antibody; Neurofilament antibody; Intermediate Neurofilament antibody
预测分子量62 kDa
翻译后修饰O-glycosylated.
Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.
Ubiquitinated in the presence of TRIM2 and UBE2D1.
检测图片 (2)
  • ARG56066 anti-Neurofilament NF-L antibody [NR-4] IHC-P image

    Immunohistochemistry: Formalin-fixed, paraffin-embedded Human cerebellum stained with ARG56066 anti-Neurofilament NF-L antibody [NR-4].

  • ARG56066 anti-Neurofilament NF-L antibody [NR-4] IHC-P image

    Immunohistochemistry: Formalin-fixed, paraffin-embedded Rat cerebellum stained with ARG56066 anti-Neurofilament NF-L antibody [NR-4].

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