anti-NFATc1 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes NFATc1
  • 反应物种: Hu
  • 应用: FACS, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: NFATc1
  • 抗原物种: Human
  • 抗原: Synthetic peptide derived from Human NFATc1.
  • Brand:
CAT.NO. : ARG40674
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes NFATc1
反应物种Hu
应用FACS, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称NFATc1
抗原物种Human
抗原Synthetic peptide derived from Human NFATc1.
偶联标记Un-conjugated
別名NFATc1; NFAT transcription complex cytosolic component; NFAT2; NF-ATC; NF-ATc; NF-ATc1; Nuclear factor of activated T-cells, cytoplasmic 1; NFATc; NF-ATc1.2
应用说明
应用建议
应用推荐稀释比
FACS1:50
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 4772 Human NFATC1

Swiss-port # O95644 Human Nuclear factor of activated T-cells, cytoplasmic 1

基因名称NFATC1
全名nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
背景介绍The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]
生物功能Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. [UniProt]
细胞定位Cytoplasm. Nucleus. [UniProt]
预测分子量101 kDa
翻译后修饰Phosphorylated by NFATC-kinase and GSK3B; phosphorylation induces NFATC1 nuclear exit and dephosphorylation by calcineurin promotes nuclear import. Phosphorylation by PKA and DYRK2 negatively modulates nuclear accumulation, and promotes subsequent phosphorylation by GSK3B or casein kinase 1. [UniProt]
检测图片 (1)
  • ARG40674 anti-NFATc1 antibody WB image

    Western blot: Ramos cell lysate stained with ARG40674 anti-NFATc1 antibody.

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