anti-NG2 / Chondroitin sulfate proteoglycan 4 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes NG2 / Chondroitin sulfate proteoglycan 4
  • 反应物种: Hu
  • 应用: IHC-P, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: NG2 / Chondroitin sulfate proteoglycan 4
  • 抗原物种: Human
  • 抗原: Synthetic peptide derived from Human NG2 / Chondroitin sulfate proteoglycan 4.
  • Brand:
CAT.NO. : ARG59471
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes NG2 / Chondroitin sulfate proteoglycan 4
反应物种Hu
应用IHC-P, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称NG2 / Chondroitin sulfate proteoglycan 4
抗原物种Human
抗原Synthetic peptide derived from Human NG2 / Chondroitin sulfate proteoglycan 4.
偶联标记Un-conjugated
別名HMW-MAA; MCSPG; Chondroitin sulfate proteoglycan NG2; MCSP; Chondroitin sulfate proteoglycan 4; MSK16; NG2; Melanoma chondroitin sulfate proteoglycan; MEL-CSPG; Melanoma-associated chondroitin sulfate proteoglycan
应用说明
应用建议
应用推荐稀释比
IHC-P1:50 - 1:200
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
属性
形式Liquid
纯化Affinity-chromatography
缓冲液PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 1464 Human CSPG4

Swiss-port # Q6UVK1 Human Chondroitin sulfate proteoglycan 4

基因名称CSPG4
全名chondroitin sulfate proteoglycan 4
背景介绍Chondroitin sulfate proteoglycan 4 (CSPG4): A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]
生物功能Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. [UniProt]
细胞定位Cell membrane; Single-pass type I membrane protein; Extracellular side. Apical cell membrane; Single-pass type I membrane protein; Extracellular side. Cell projection, lamellipodium membrane; Single-pass type I membrane protein; Extracellular side. Cell surface. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes. [UniProt]
产品亮点Related Antibody Duos and Panels:
ARG30328 Angiogenesis Antibody Panel
Related products:
NG2 antibodies; NG2 ELISA Kits; NG2 Duos / Panels; Anti-Rabbit IgG secondary antibodies;
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预测分子量251 kDa
翻译后修饰O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4.

Phosphorylation by PRKCA regulates its subcellular location and function in cell motility. [UniProt]
检测图片 (1)
  • ARG59471 anti-NG2 / Chondroitin sulfate proteoglycan 4 antibody WB image

    Western blot: A375 cell lysate stained with ARG59471 anti-NG2 / Chondroitin sulfate proteoglycan 4 antibody.

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