anti-NLRP10 / NALP10 antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes NLRP10 / NALP10
  • 反应物种: Hu, Ms, Rat
  • 应用: WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: NLRP10 / NALP10
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 1-300 of Human NLRP10 / NALP10 (NP_789791.1).
  • Brand:
CAT.NO. : ARG43220
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes NLRP10 / NALP10
反应物种Hu, Ms, Rat
应用WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称NLRP10 / NALP10
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 1-300 of Human NLRP10 / NALP10 (NP_789791.1).
偶联标记Un-conjugated
別名CLR11.1; PAN5; Nucleotide-binding oligomerization domain protein 8; NALP10; PYNOD; NACHT, LRR and PYD domains-containing protein 10; NOD8
应用说明
预测反应性说明Mouse, Rat
应用建议
应用推荐稀释比
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照HT-29
实际分子量~ 75 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 244202 Mouse NLRP10

GeneID: 338322 Human NLRP10

Swiss-port # Q86W26 Human NACHT, LRR and PYD domains-containing protein 10

Swiss-port # Q8CCN1 Mouse NACHT, LRR and PYD domains-containing protein 10

基因名称NLRP10
全名NLR family, pyrin domain containing 10
背景介绍Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]
生物功能Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819). [UniProt]
细胞定位Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection. [UniProt]
预测分子量75 kDa
检测图片 (1)
  • ARG43220 anti-NLRP10 / NALP10 antibody WB image

    Western blot: 25 µg of HT-29 cell lysate stained with ARG43220 anti-NLRP10 / NALP10 antibody at 1:1000 dilution.

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