anti-NLRP2 / NALP2 antibody
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 同位型:
- 靶点名称:
- 抗原物种:
- 抗原:
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Brand:
CAT.NO. : ARG42965
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NLRP2 / NALP2 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NLRP2 / NALP2 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein corresponding to F9-K190 of Human NLRP2 / NALP2. |
| 偶联标记 | Un-conjugated |
| 別名 | PAN1; PYPAF2; PYRIN-containing APAF1-like protein 2; NALP2; NACHT, LRR and PYD domains-containing protein 2; CLR19.9; NBS1; Nucleotide-binding site protein 1; PYRIN domain and NACHT domain-containing protein 1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | ~ 120 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9NX02 Human NACHT, LRR and PYD domains-containing protein 2 |
|---|---|
| 基因名称 | NLRP2 |
| 全名 | NLR family, pyrin domain containing 2 |
| 背景介绍 | This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016] |
| 生物功能 | Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 121 kDa |
检测图片 (2)
ARG42965 anti-NLRP2 / NALP2 antibody WB image
Western blot: 50 µg of sample under reducing conditions. Human placenta, K562 and A549 whole cell lysates stained with ARG42965 anti-NLRP2 / NALP2 antibody at 0.5 µg/ml dilution, overnight at 4°C.
ARG42965 anti-NLRP2 / NALP2 antibody WB image
Western blot: 50 µg of sample under reducing conditions. Mouse lung lysate stained with ARG42965 anti-NLRP2 / NALP2 antibody at 0.5 µg/ml dilution, overnight at 4°C.
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