anti-NM23A antibody [5F4]
![anti-NM23A antibody [5F4]](/upload/image/products/ARG57180_WB_2_210_205.jpg)
![anti-NM23A antibody [5F4]](/upload/image/products/ARG57180_WB_1.jpg)
![anti-NM23A antibody [5F4]](/upload/image/products/ARG57180_WB_2.jpg)
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 宿主:
- 克隆:
- 克隆号:
- 同位型:
- 靶点名称:
- 抗原物种:
-
Brand:
CAT.NO. : ARG57180
US＄ Please choose
US＄ Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
概述
| 产品描述 | Mouse Monoclonal antibody [5F4] recognizes NM23A |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 5F4 |
| 同位型 | IgG2b, kappa |
| 靶点名称 | NM23A |
| 抗原物种 | Human |
| 抗原 | Recombinant fragment around aa. 1-152 of Human NM23A |
| 偶联标记 | Un-conjugated |
| 別名 | NDP kinase A; NDPK-A; NM23; Nucleoside diphosphate kinase A; Granzyme A-activated DNase; NDKA; NBS; NM23-H1; NB; NDPKA; NDK A; Tumor metastatic process-associated protein; EC 2.7.4.6; GAAD; AWD; Metastasis inhibition factor nm23 |
应用说明
| 应用建议 |
| ||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 10% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NME1 |
| 全名 | NME/NM23 nucleoside diphosphate kinase 1 |
| 背景介绍 | This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008] |
| 生物功能 | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. [UniProt] |
| 预测分子量 | 17 kDa |
检测图片 (2)
ARG57180 anti-NM23A antibody [5F4] WB image
Western blot: 40 µg of 1) HeLa, 2) A549, 3) Jurkat, 4) HepG2, 5) MCF7, and 6) PC3 cell lysates stained with ARG57180 anti-NM23A antibody [5F4] at 1:1000.
ARG57180 anti-NM23A antibody [5F4] WB image
Western blot: 50 ng of 1) NME1, 2) NME2, 3) NME3, and 4) NME4 recombinant proteins stained with ARG57180 anti-NM23A antibody [5F4] at 1:1000.
New Products
