anti-NMDAR2A antibody, N-terminal
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- 应用:
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Brand:
CAT.NO. : ARG52360
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Product Details
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes NMDAR2A |
|---|---|
| 反应物种 | Ms, Rat |
| 预测物种 | Bov, Dog |
| 应用 | ICC/IF, IHC-Fr, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | NMDAR2A |
| 抗原物种 | Rat |
| 抗原 | Synthetic peptide corresponding to amino acid residues from the N-terminal region of the NR2A subunit conjugated to KLH |
| 偶联标记 | Un-conjugated |
| 別名 | FESD; NR2A; GluN2A; Glutamate receptor ionotropic, NMDA 2A; N-methyl D-aspartate receptor subtype 2A; EPND; Glutamate [NMDA] receptor subunit epsilon-1; NMDAR2A; LKS; hNR2A |
应用说明
| 应用建议 |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | Specific for the ~180k NR2A subunit of the NMDA receptor. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P35436 Mouse Glutamate receptor ionotropic, NMDA 2A Swiss-port # Q00959 Rat Glutamate receptor ionotropic, NMDA 2A |
|---|---|
| 基因名称 | GRIN2A |
| 全名 | glutamate receptor, ionotropic, N-methyl D-aspartate 2A |
| 背景介绍 | The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. |
| 研究领域 | Neuroscience antibody; Postsynaptic Receptor antibody |
| 预测分子量 | 165 kDa |
检测图片 (1)
ARG52360 anti-NMDAR2A antibody, N-terminal WB image
Western Blot: 10 μg of rat hippocampal lysate showing specific immunolabeling of the ~ 180k NR2A subunit stained with NMDAR2A antibody (ARG52360)
参考文献
Involvement of NMDAR/PSD-95/nNOS-NO-cGMP pathway in embryonic exposure to BPA induced learning and memory dysfunction of rats.
WB / Rat
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