anti-NSFL1C antibody

Key features and details

  • 产品描述: Rabbit Polyclonal antibody recognizes NSFL1C
  • 反应物种: Hu, Ms, Rat
  • 应用: ICC/IF, IP, WB
  • 宿主: Rabbit
  • 克隆: Polyclonal
  • 同位型: IgG
  • 靶点名称: NSFL1C
  • 抗原物种: Human
  • 抗原: Recombinant fusion protein corresponding to aa. 1-185 of Human NSFL1C (NP_057227.2).
  • Brand:
CAT.NO. : ARG59944
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Product Details
概述
产品描述Rabbit Polyclonal antibody recognizes NSFL1C
反应物种Hu, Ms, Rat
应用ICC/IF, IP, WB
宿主Rabbit
克隆Polyclonal
同位型IgG
靶点名称NSFL1C
抗原物种Human
抗原Recombinant fusion protein corresponding to aa. 1-185 of Human NSFL1C (NP_057227.2).
偶联标记Un-conjugated
別名p97 cofactor p47; dJ776F14.1; UBXD10; UBX domain-containing protein 2C; NSFL1 cofactor p47; UBX1; UBXN2C; P47
应用说明
应用建议
应用推荐稀释比
ICC/IF1:50 - 1:200
IP1:50 - 1:100
WB1:500 - 1:2000
应用说明* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量41 kDa
属性
形式Liquid
纯化Affinity purified.
缓冲液PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂0.02% Sodium azide
稳定剂50% Glycerol
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
数据库连接

GeneID: 386649 Mouse NSFL1C

GeneID: 55968 Human NSFL1C

GeneID: 83809 Rat NSFL1C

基因名称NSFL1C
全名NSFL1 (p97) cofactor (p47)
背景介绍N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011]
生物功能Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro). [UniProt]
细胞定位Nucleus. Golgi apparatus, Golgi stack. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase. [UniProt]
预测分子量41 kDa
翻译后修饰Phosphorylated during mitosis. Phosphorylation inhibits interaction with Golgi membranes and is required for the fragmentation of the Golgi stacks during mitosis (By similarity). [UniProt]
检测图片 (2)
  • ARG59944 anti-NSFL1C antibody ICC/IF image

    Immunofluorescence: HeLa cells stained with ARG59944 anti-NSFL1C antibody.

  • ARG59944 anti-NSFL1C antibody IP image

    Immunoprecipitation: 200 µg extracts of A549 cells immunoprecipitated and stained with ARG59944 anti-NSFL1C antibody at 1:1000 dilution.

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